I plan on sending an email to 10k+ email addresses (mostly gmail and yahoo) to announce the launch of my startup's product. I'm planning on using PHPMailer or PHPList to send out the mails.

I've never mass-mailed before and had a few basic questions. I've already browsed through some of the other mass-mail threads on this forum but the questions remain hence a new thread.

1. Are newsletters which are sent by so many other organizations sent out in a similar manner - using programs such as PHPMailer or PHPList?

2. When would a GMail or a Yahoo blacklist my domain name - are there any set parameters - 1000 emails in an hour would result in getting banned or some such parameters? If yes, then what sort of settings should I take note of when sending the emails - any format of the email or spread out the 10+ emails over 2 days etc.?

3. If a Gmail or a Yahoo blacklists your domain name - is there any way to get out of the blacklist?