Before you answer this I have never developed anything popular enough to attain high server loads. Treat me as (sigh) an alien that has just landed on the planet, albeit one that knows PHP and a few optimisation techniques.

I'm developing a tool in PHP that could attain quite a lot of users, if it works out right. However while I'm fully capable of developing the program I'm pretty much clueless when it comes to making something that can deal with huge traffic. So here's a few questions on it (feel free to turn this question into a resource thread as well).

Databases

At the moment I plan to use the MySQLi features in PHP5. However how should I setup the databases in relation to users and content? Do I actually need multiple databases? At the moment everything's jumbled into one database - although I've been considering spreading user data to one, actual content to another and finally core site content (template masters etc.) to another. My reasoning behind this is that sending queries to different databases will ease up the load on them as one database = 3 load sources. Also would this still be effective if they were all on the same server?

Caching

I have a template system that is used to build the pages and swap out variables. Master templates are stored in the database and each time a template is called it's cached copy (a html document) is called. At the moment I have two types of variable in these templates - a static var and a dynamic var. Static vars are usually things like page names, the name of the site - things that don't change often; dynamic vars are things that change on each page load.

My question on this:

Say I have comments on different articles. Which is a better solution: store the simple comment template and render comments (from a DB call) each time the page is loaded or store a cached copy of the comments page as a html page - each time a comment is added/edited/deleted the page is recached.

Finally

Does anyone have any tips/pointers for running a high load site on PHP. I'm pretty sure it's a workable language to use - Facebook and Yahoo! give it great precedence - but are there any experiences I should watch out for?

Thanks, Ross