Right now I'm developing the prototype of a web application that aggregates large number of text entries from a large number of users. This data must be frequently displayed back and often updated. At the moment I store the content inside a MySQL database and use NHibernate ORM layer to interact with the DB. I've got a table defined for users, roles, submissions, tags, notifications and etc. I like this solution because it works well and my code looks nice and sane, but I'm also worried about how MySQL will perform once the size of our database reaches a significant number. I feel that it may struggle performing join operations fast enough.

This has made me think about non-relational database system such as MongoDB, CouchDB, Cassandra or Hadoop. Unfortunately I have no experience with either. I've read some good reviews on MongoDB and it looks interesting. I'm happy to spend the time and learn if one turns out to be the way to go. I'd much appreciate any one offering points or issues to consider when going with none relational dbms?