Outlook 2010 on WinXP runs once then refuses to run again until reboot

Posted by msorens on Super User See other posts from Super User or by msorens
Published on 2011-01-07T23:42:28Z Indexed on 2011/01/07 23:56 UTC
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Since I installed Outlook 2010 on a new machine (WinXP Pro SP3) a couple months back I have had an issue that is quite annoying: If I close Outlook then attempt to restart it I get a small pop-up saying only: "Cannot start Microsoft Outlook". I found one workaround, but not a terribly practical one: reboot. If I reboot then launch Outlook, it opens fine.

Here is what I know:

  • Since I can run Outlook just fine after a reboot, I do not see that a system restore, an OS reinstall, or the like would help.
  • I tried "outlook.exe /resetnavpane" and "outlook.exe /safe" but those give the same error.
  • There are no entries in the event log.
  • There is no instance of Outlook appearing in the process list once I close the program, so it does not seem to be an alias for "outlook is already running".

As far as I have found, my situation is unique among reports of similar incidents: I have uncovered no other reports saying Outlook would run fine the first launch or that a reboot would again allow it to run.

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