I really like following style standards, as those specified in PEP 8. I have a linter that checks it automatically, and definitely my code is much better because of that.
There is just one point in PEP 8, the E251 & E221 don't feel very good. Coming from a JavaScript background, I used to align the variable assignments as following:
var var1        = 1234;
    var2        = 54;
    longer_name = 'hi';
var lol = {
    'that'        : 65,
    'those'       : 87,
    'other_thing' : true
};
And in my humble opinion, this improves readability dramatically. Problem is, this is dis-recommended by PEP 8. With dictionaries, is not that bad because spaces are allowed after the colon:
dictionary = {
   'something':        98,
   'some_other_thing': False
}
I can "live" with variable assignments without alignment, but what I don't like at all is not to be able to pass named arguments in a function call, like this:
some_func(length=      40,
          weight=      900,
          lol=         'troll',
          useless_var= True,
          intelligence=None)
So, what I end up doing is using a dictionary, as following:
specs = {
    'length':       40,
    'weight':       900,
    'lol':          'troll',
    'useless_var':  True,
    'intelligence': None
}
some_func(**specs)
or just simply
some_func(**{'length':       40,
             'weight':       900,
             'lol':          'troll',
             'useless_var':  True,
             'intelligence': None})
But I have the feeling this work around is just worse than ignoring the PEP 8 E251 / E221.
What is the best practice?