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• Windows Phone 7, taking the mobile out of mobile

  - by markritchie

  I’ll start off this blog entry with a little background which is necessary for you to understand my situation. I moved from to the UK to Germany about three years ago and while I can converse in German, English is still very much my first language and the language I want my content delivered in. I happily purchased a HTC HD7 when WP7 was released here in Germany thinking foolishly that Microsoft really would get internationalization and localization as it’s at the heart of their business and developer products. Overall I’m very happy with my WP7, the camera sucks but that’s more HTC’s fault that Microsoft, but other than that it’s a very promising platform. My problems started when I purchased my first app. Initially everything appeared to be fine and things were as smooth as things had been with my previous free applications, however about a month after I received an email from Zune informing me that the credit card that they had registered against my account had expired. No problem I foolishly thought; I’ll simply add a new one. I don’t want to bore you with the details of what I’ve been through other than to take the low-lights: trying numerous websites, posts on Microsoft Answers and a tweet to Microsoft Support all to no avail. Today somebody suggested that I call the Xbox support line in the UK as they had solved their billing problems this way. So I called up the Xbox support line since I hadn’t resolved the problem using the Zune portal to resolve my problem with my WP7 (anybody else thinks Microsoft might need some consolidation here). After being on the phone with a very friendly representative in Ireland I was informed that because my British credit card has a billing address in Germany they are unable to accept it as a credit card. Because my Live ID and Zune Tag are registered in the UK they cannot take my card. Their solution is that I have to create a new Zune Tag that has its locale in Germany and then associate it with my phone. Now, first thing I go to register for a Zune Tag with a German locale it very kindly switches into German for me, nothing quite like reading a EULA in a language you’re not fluent in. I’ve no idea how this will affect the apps that are available to me in the app store, and I’m pretty sure it means that all my Xbox live achievements will become history. And what if I was to move to say France at some point do I have to go through all this again? At the end of the day I’m trying to set something up so I can give them my money and they’re making it VERY difficult for me. Could you imagine walking into a book store when you were on holiday and being told by the clerk that they couldn’t take your credit card because you came from another country?

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• Which one to select for my future career; Java, C#, Azure or Apex?

  - by user636195

  Hi folks, This time, I am going to studying Masters in Computer Science in U.S.A after a week. I have been doing my B.Sc for the past three years and after my freshman year I started working on projects (in C# and very rarely in Java) for the past two years.(i.e while I was a second and third year student). Now I am in a college where all of the programming courses are going to be taken in Java only (using Eclipse) and I am going to stay in this college for 8 months on campus and then fully employed for two years in other companies as a CPT. I really love to work on Microsoft products because, for me, they are simple and easy to use and understand. My future plan is to work in Cloud computing and be a Cloud based business owner in the near future. Since the college is going to teach us and let us do every project in Java, I was confused which programming language to use that will help me and enhance me in my career, and of course I wanted to select the one I liked to do everytime. I also heard a lot about Azure (Microsoft’s ) and Apex (Salesforce.com’s cloud computing programming language). Would you please give me your advice and recommendation based on my situation? Should I have to study only Java, or should I have to study C# or Azure beside Java on my own? The reason I asked this is because, since I have no clue how Azure works and how long it will take me to know the language, I am really confused which one to select (Java Vs C# and Azure Vs Apex or if there is any popular and mostly used Cloud Computing langauge). Do you think I can get a job in cloud computing if I study Azure or Apex by my own without experience? There is also one issue I want to consider which is a short term issue is. i.e Salary. Since I have to pay my student loan, I also need to get a good job which will let me pay my loan within two years. But, as I said, my long term plan is, get experience in Cloud Computing (from programming to administrative part,i.e every area of cloud computing) and then have my own business may be within 5-10 years. What do you think? Thank you for your time.

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• Learning to program in the modern era?

  - by BBHorus

  At this time, lets say in the modern era, in which order do you organize a programing course for teaching and/or learning, what should be learned first, what should emphasize: Databases Data structures Design patterns Programing paradigms(Procedural, functional, OOP, ...etc ) Operating System Some specific programing language What about English if you are not native speaker or doesn't know English AI Anything else... I ask this because in the university that I went, the programing course was awful it was not focus on what you were going to see out when you work what you were supposed to learn. PS: Again sorry about my English is not my main language. ...Experts and gurus please share

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• Is it possible to grant access to a folder in a SVN server using SVN's API?

  - by Splendonia

  I need to develop a web application (Using any language but I'm familiar with Frameworks Symfony2 and Rails), that is able to grant access to a user to a determined folder on another server on the same network from the application's front-end. I found out that SVN has an API and that I could interact with it with PHP or Ruby (Apparently), although I would be willing to program the application on another language, the server where the files are stored is using Windows and I thought on using Virtual SVN server, however I can't find any function on the API to grant users access to files and/or folders or access of any kind, like you usually do using the GUI (VirtualSVN on Windows). Am I missing anything? Is this even possible?

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• STL for games, yea or nay?

  - by munificent

  Every programming language has its standard library of containers, algorithms, and other helpful stuff. With languages like C#, Java, and Python, it's practically inconceivable to use the language without its standard lib. Yet, on many C++ games I've worked on, we either didn't use the STL at all, used a tiny fraction of it, or used our own implementation. It's hard to tell if that was a sound decision for our games, or one simply made out of ignorance of the STL. So... is the STL a good fit or not?

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• Modern website/webapp setup

  - by onepiece

  I'm new to web development. From looking at popular open-source frameworks for both front-end and back-end, I have a general idea of what the modern full-stack web setup looks like: Database <- Back-end language ~ REST API <- Front-end Notes: The back-end language (Python, Ruby, PHP, Java) generates the API, which is the only layer between the back and the front. The API will have authentication to protect private data. The front-end sends GET and POST requests to the API. A MVC framework can be used, such as Backbone, Angular, or Ember.js. Does this align with best practices for web development?

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• Are there some types of software that cannot be developed by all major programming languages?

  - by mbillard

  I'd like to know if some of the major programming languages can absolutely not be used to create some very specific types of software. By major programming language I mean the likes of C++, C#, Java, Ruby, Python. By "cannot be developed" I mean cannot be developed or it is unrealistic to do it due to performance, difficulty of implementation, etc. I've always thought that any programming language could be used to solve any problem but lately I've been thinking that some languages are unsuitable for some projects. If you can provide examples of such applications, it would be appreciated. Thanks.

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• Does Turing-complete implies possibility of malware? [closed]

  - by Mathematician82

  Is it possible to build an operating system that contains some Turing complete compiler (language?) but is unable to run any malware? Or is there any definition for a malware? This question popped on my mind as I was wondering why Windows has more malware than Linux. If Linux contains a C programming language and its compiler, I think it is possible to write a Linux program that works similarly than Windows viruses. But there are less malware for Linux than for Windows although there is a Wine for Linux to simulate Windows programs.

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• Has Dart something useful that javascript doesn't have?

  - by marko

  http://www.dartlang.org/ I've checked out the site very briefly, and got curious. Is there any advantages of using Dart? Is it just a replacement for javascript? It looks like simpler java. Writing quite a lot of C# at work, the language feels very much like what I'm used to, so learning the syntax looks like a breeze to learn. Has anybody any opinions or experiences with the language? (Compared to coffeescript (= I'm not doing ruby syntax) the syntax looks more familiar to me).

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• STL for games, yea or nay?

  - by munificent

  Every programming language has its standard library of containers, algorithms, and other helpful stuff. With languages like C#, Java, and Python, it's practically inconceivable to use the language without its standard lib. Yet, on many C++ games I've worked on, we either didn't use the STL at all, used a tiny fraction of it, or used our own implementation. It's hard to tell if that was a sound decision for our games, or one simply made out of ignorance of the STL. So... is the STL a good fit or not?

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• Would you see any use of a Trilean (True, False, ??)

  - by Sybiam

  I don't know if I'm alone but sometimes I have a function that should return true or false. But in some case there would be a third result that would make more sense. In some language theses cases would be handled with integers or with exception. For exemple you want to handle the age of a user if he is over 18 years old. And you have a function like this. if(user.isAdult(country_code)){ //Go On }else{ // Block access or do nothing } But in some case depending how your app is built I could see case where the birthday field is incomplete. Then this function should return something undetermined. switch(user.isAdult()){ case true: // go on break; case undetermined: //Inform user birthday is incomplete case false: //Block access } As i said we can handle that with Exceptions and Int, but I would find it quite sexy to have a true, false, undetermined embeded in the language instead of using some home defined constants.

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• Is C# becoming harder to read? [closed]

  - by Avi

  As C# has progressed, many language features have been added. It has come to the point where it's becoming unreadable for me. As an example, consider the following code snip from Caliburn.Micro code here: container = CompositionHost.Initialize( new AggregateCatalog( AssemblySource.Instance. Select(x => new AssemblyCatalog(x)) .OfType<ComposablePartCatalog>() ) ); Now, this is just a small example. I have a number of questions: Is this a common or known problem? Is the C# community finding the same? Is this an issue with the language, or is it the style used by the developer? Are there any simple solutions to better understand others code and avoid writing code in this way?

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• Visual Basic for Beginners

  If you want to learn how to program in Visual Basic this tutorial can help you get started in a few simple steps. Visual Basic or VB is a great programming language commonly used for developing Windows programs and applications. It is also used as a server side programming language on the ASP.NET platform along with C# and other languages supported by the .NET framework.... Network Management Software Automate Real Time Network Analysis & IP Mapping. Try NetMRI for Free.

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• How easy is it to change languages/frameworks professionally? [closed]

  - by user924731

  Forgive me for asking a career related question - I know that they can be frowned upon here, but I think that this one is general enough to be useful to many people. My question is: How easy/difficult is it to get a job using language/frameowork B, when your current job uses language/framework A? e.g. If you use C#/ASP.NET in your current job, how difficult would it be to get a job using python/django, or PHP/Zend, or whatever (the specifics of the example don't matter). Relatedly, if you work in client side scripting, but perhaps work on server-side projects in your own time, how difficult would it be to switch to server-side professionally? So, to sum up, does the choice of which languages/frameworks use at work tend to box you in professionally?

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• How to start cross-platform desktop game development? [closed]

  - by Wamer

  I am interested in developing some 2d game since I have graduated and got some time to spare. I am looking for some advices where to start and with what. My main target platforms are Mac and Windows (later porting/rewriting/modifying for iOS, Android or WP7 is considerable). I need some advices about language I should choose, frameworks, engines and this kind of stuff. I gotta start somehow, but first of all I need to know how. Choosing good language with great framework/engine is key to ongoing successful game development I think.

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• What are the Open Source alternatives to WPF/XAML?

  - by Evan Plaice

  If we've learned anything from HTML/CSS it's that, declarative languages (like XML) work best to describe User Interfaces because: It's easy to build code preprocessors that can template the code effectively. The code is in a well defined well structured (ideally) format so it's easy to parse. The technology to effectively parse or crawl an XML based source file already exists. The UIs scripted code becomes much simpler and easier to understand. It simple enough that designers are able to design the interface themselves. Programmers suck at creating UIs so it should be made easy enough for designers. I recently took a look at the meat of a WPF application (ie. the XAML) and it looks surprisingly familiar to the declarative language style used in HTML. It's apparent to me that the current state of desktop UI development is largely fractionalized, otherwise there wouldn't be so much duplicated effort in the domain of graphical user interface design (IE. GTK, XUL, Qt, Winforms, WPF, etc). There are 45 GUI platforms for Python alone It's seems reasonable to me that there should be a general purpose, open source, standardized, platform independent, markup language for designing desktop GUIs. Much like what the W3C made HTML/CSS into. WPF, or more specifically XAML seems like a pretty likely step in the right direction. Now that the 'browser wars' are over should we look forward to a future of 'desktop gui wars?' Note: This topic is relatively subjective in the attempt to be 'future-thinking.' I think that desktop GUI development in its current state sucks ((really)hard) and, even though WPF is still in it's infancy, it presents a likely solution to the problem. Update: Thanks a lot for the info, keep it comin'. Here's are the options I've gathered from the comments and answers. GladeXML Editor: Glade Interface Designer OS Platforms: All GUI Platform: GTK+ Languages: C (libglade), C++, C# (Glade#), Python, Ada, Pike, Perl, PHP, Eiffel, Ruby XRC (XML Resource) Editors: wxGlade, XRCed, wxDesigner, DialogBlocks (non-free) OS Platforms: All GUI Platform: wxWidgets Languages: C++, Python (wxPython), Perl (wxPerl), .NET (wx.NET) XML based formats that are either not free, not cross-platform, or language specific XUL Editor: Any basic text editor OS Platforms: Any OS running a browser that supports XUL GUI Platform: Gecko Engine? Languages: C++, Python, Ruby as plugin languages not base languages Note: I'm not sure if XUL deserves mentioning in this list because it's less of a desktop GUI language and more of a make-webapps-run-on-the-desktop language. Plus, it requires a browser to run. IE, it's 'DHTML for the desktop.' CookSwing Editor: Eclipse via WindowBuilder, NetBeans 5.0 (non-free) via Swing GUI Builder aka Matisse OS Platforms: All GUI Platform: Java Languages: Java only XAML (Moonlight) Editor: MonoDevelop OS Platforms: Linux and other Unix/X11 based OSes only GUI Platforms: GTK+ Languages: .NET Note: XAML is not a pure Open Source format because Microsoft controls its terms of use including the right to change the terms at any time. Moonlight can not legally be made to run on Windows or Mac. In addition, the only platform that is exempt from legal action is Novell. See this for a full description of what I mean.

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• What do I need to write a small game on Linux?

  - by Michas

  I want to make a simple game: 2d, single-player, without tons of animations and special effects. I am not interested in ready to use game engines, I want to learn to write some code in a quite universal language. I am using Linux (AMD64) and looking for something easy with nice library for games. I do not want to mix few languages, most of them are in fact fast enough themselves for my needs. Cross platform would be an advantage, however all I need is a good Linux support. I have been considering few solutions. Ruby + Language looks very nice. + I am going to learn Ruby. - I am afraid I can have problems with additional libraries. - This thread about game libraries for Ruby could be longer. SDL + C + It is used for games. + It is very easy to set up. + There is a lot of additional libraries. + It is cross-platform. - The solution is quite low level. - The language is sometimes quite hard to read. QT + C++ + It is very easy to set up. + The standard QT libraries supports everything I can possibly need. + It is cross-platform. + The documentation is good. - The compilation is slow. - The language looks horrible. - The size of standard QT libraries is too big to comprehend. Environment of web browser + I am going to learn something more about this environment. + It is somewhat used for games. + It is quite cross-platform. - It would be too much experimental. Java + It is used for games. + The standard Java libraries supports everything I can possibly need. + It is cross-platform. - It is quite hard to set up. - The size of standard Java libraries is too big to comprehend. - The source code in Java could look better. - I think I do not want to learn Java. Google Go + I am going to learn Google Go. - There is big problem with libraries. - The solution would be quite low level. Python + It looks some people do games in Python, according to this thread. + It looks there are probably more libraries than for Ruby. - The Ruby language looks better. - I think I do not want to learn Python. C++ + something else + It is used for games. + It would be probably cross-platform. + There is a lot of libraries. - I do not need C++ extensions over C. - Compilation could be slow, there are fast compilers for C, not for C++. Haskell + I am going to learn Haskell. - Many things about programming computer games looks too much imperative. - It looks I can have some problems with libraries. - Compilation (GHC) looks slow. There is probably something more to consider. Does anyone have experience in making small games for Linux in non mainstream solutions? Does anyone have an advice for me?

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• sometime SetCookie() not working

  - by Nano HE

  Hi I created two file to switch my forum (Language Chinese and English) enForum.php <?php function foo() { global $_COOKIES; setcookie('ForumLangCookie', 'en', time()+3600, '/', '.mysite.com'); echo 'running<br>'; $_COOKIES['ForumLangCookie'] = 'en'; bar(); } // foo() function bar() { global $_COOKIES; if (empty($_COOKIES['ForumLangCookie'])) { die('cookie_name is empty'); } echo 'Language =' . $_COOKIES['ForumLangCookie']; echo "<br>"; } // bar() foo(); ?> <!DOCTYPE HTML PUBLIC "-//W3C//DTD HTML 4.01 Transitional//EN"> <html> <head> <title>forum EN Version</title> <meta http-equiv="Content-Type" content="text/html; charset=iso-8859-1"> </head> <body> please be patient ... <script LANGUAGE='javascript'> location.href='http://www.mysite.com/forum/index.php'; </script> </body> </html> cnForum.php <?php function foo() { global $_COOKIES; setcookie('ForumLangCookie', 'cn', time()+3600, '/', '.mysite.com'); echo 'running<br>'; $_COOKIES['ForumLangCookie'] = 'cn'; bar(); } // foo() function bar() { global $_COOKIES; if (empty($_COOKIES['ForumLangCookie'])) { die('cookie_name is empty'); } echo 'Language =' . $_COOKIES['ForumLangCookie']; echo "<br>"; } // bar() foo(); ?> <!DOCTYPE HTML PUBLIC "-//W3C//DTD HTML 4.01 Transitional//EN"> <html> <head> <title>forum CN Version</title> <meta http-equiv="Content-Type" content="text/html; charset=utf-8"> </head> <body> please be patient ... <script LANGUAGE='javascript'> location.href='http://www.mysite.com/forum/index.php'; </script> </body> </html> There are some files including include template('foo'); , I will get the Cookie value and load different template files. But sometime the SetCookie() not working. Do I need add Sleep(someSeconds); for my code?

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• Relation between [[Prototype]] and prototype in JavaScript

  - by Claudiu

  From http://www.jibbering.com/faq/faq_notes/closures.html : Note: ECMAScript defines an internal [[prototype]] property of the internal Object type. This property is not directly accessible with scripts, but it is the chain of objects referred to with the internal [[prototype]] property that is used in property accessor resolution; the object's prototype chain. A public prototype property exists to allow the assignment, definition and manipulation of prototypes in association with the internal [[prototype]] property. The details of the relationship between to two are described in ECMA 262 (3rd edition) and are beyond the scope of this discussion. What are the details of the relationship between the two? I've browsed through ECMA 262 and all I've read there is stuff like: The constructor’s associated prototype can be referenced by the program expression constructor.prototype, Native ECMAScript objects have an internal property called [[Prototype]]. The value of this property is either null or an object and is used for implementing inheritance. Every built-in function and every built-in constructor has the Function prototype object, which is the initial value of the expression Function.prototype Every built-in prototype object has the Object prototype object, which is the initial value of the expression Object.prototype (15.3.2.1), as the value of its internal [[Prototype]] property, except the Object prototype object itself. From this all I gather is that the [[Prototype]] property is equivalent to the prototype property for pretty much any object. Am I mistaken?

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• How can I access the group of a linq group-by query from a nested repeater control?

  - by Duke

  I'm using a linq group by query (with two grouping parameters) and would like to use the resulting data in a nested repeater. var dateGroups = from row in data.AsEnumerable() group row by new { StartDate = row["StartDate"], EndDate = row["EndDate"] }; "data" is a DataTable from an SqlDataAdapter-filled DataSet. "dateGroups" is used in the parent repeater, and I can access the group keys using Eval("key.StartDate") and Eval("key.EndDate"). Since dateGroups actually contains all the data rows grouped neatly by Start/End date, I'd like to access those rows to display the data in a child repeater. To what would I set the child repeater's DataSource? I have tried every expression in markup I could think of; I think the problem is that I'm trying to access an anonymous member (and I don't know how.) In case it doesn't turn out to be obvious, what would be the expression to access the elements in each iteration of the child repeater? Is there an expression that would let me set the DataSource in the markup, or will it have to be in the codebehind on some event in the parent repeater?

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• Good grammar for date data type for recursive descent parser LL(1)

  - by Totophil

  I'm building a custom expression parser and evaluator for production enviroment to provide a limited DSL to the users. The parser itself as the DSL, need to be simple. The parser is going to be built in an exotic language that doesn't support dynamic expression parsing nor has any parser generator tools available. My decision is to go for recursive descent approach with LL(1) grammar, so that even programmers with no previous experience in evaluating expression could quickly learn how the code works. It has to handle mixed expressions made up of several data types: decimals, percentages, strings and dates. And dates in the format of dd/mm/yyyy are easy to confuse with a string of devision ops. Is where a good solution to this problem? My own solution that is aimed at keeping the parser simple involves prefixing dates with a special symbol, let's say apostrophe: <date> ::= <apostr><digit><digit>/<digit><digit>/<digit><digit><digit><digit> <apostr> ::= ' <digit> ::= '0'..'9'

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• Why does division yield a vastly different result than multiplication by a fraction in floating points.

  - by Avram

  I understand why floating point numbers can't be compared, and know about the mantissa and exponent binary representation, but I'm no expert and today I came across something I don't get: Namely lets say you have something like: float denominator, numerator, resultone, resulttwo; resultone = numerator / denominator; float buff = 1 / denominator; resulttwo = numerator * buff; To my knowledge different flops can yield different results and this is not unusual. But in some edge cases these two results seem to be vastly different. To be more specific in my GLSL code calculating the Beckmann facet slope distribution for the Cook-Torrance lighitng model: float a = 1 / (facetSlopeRMS * facetSlopeRMS * pow(clampedCosHalfNormal, 4)); float b = clampedCosHalfNormal * clampedCosHalfNormal - 1.0; float c = facetSlopeRMS * facetSlopeRMS * clampedCosHalfNormal * clampedCosHalfNormal; facetSlopeDistribution = a * exp(b/c); yields very very different results to float a = (facetSlopeRMS * facetSlopeRMS * pow(clampedCosHalfNormal, 4)); facetDlopeDistribution = exp(b/c) / a; Why does it? The second form of the expression is problematic. If I say try to add the second form of the expression to a color I get blacks, even though the expression should always evaluate to a positive number. Am I getting an infinity? A NaN? if so why?

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• Programming R/Sweave for proper \Sexpr output

  - by deoksu

  Hi I'm having a bit of a problem programming R for Sweave, and the #rstats twitter group often points here, so I thought I'd put this question to the SO crowd. I'm an analyst- not a programmer- so go easy on me my first post. Here's the problem: I am drafting a survey report in Sweave with R and would like to report the marginal returns in line using \Sexpr{}. For example, rather than saying: Only 14% of respondents said 'X'. I want to write the report like this: Only \Sexpr{p.mean(variable)}$\%$ of respondents said 'X'. The problem is that Sweave() converts the results of the expression in \Sexpr{} to a character string, which means that the output from expression in R and the output that appears in my document are different. For example, above I use the function 'p.mean': p.mean<- function (x) {options(digits=1) mmm<-weighted.mean(x, weight=weight, na.rm=T) print(100*mmm) } In R, the output looks like this: p.mean(variable) >14 but when I use \Sexpr{p.mean(variable)}, I get an unrounded character string (in this case: 13.5857142857143) in my document. I have tried to limit the output of my function to 'digits=1' in the global environment, in the function itself, and and in various commands. It only seems to contain what R prints, not the character transformation that is the result of the expression and which eventually prints in the LaTeX file. as.character(p.mean(variable)) >[1] 14 >[1] "13.5857142857143" Does anyone know what I can do to limit the digits printed in the LaTeX file, either by reprogramming the R function or with a setting in Sweave or \Sexpr{}? I'd greatly appreciate any help you can give. Thanks, David

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• Regex For Finding Ctypes with Int32

  - by Stefan H

  (Hey all, I am looking for a little regex help... I am trying to find all CType(expression,Int32) s and replace them with CInt(expression) This, however, is proving quite difficult, considering there could be a nested Ctype(expression, Int32) within the regex match. Does anyone have any ideas for how to best go about doing this? Here is what I have now: Dim str As String = "CType((original.Width * CType((targetSize / CType(original.Height, Single)), Single)), Int32)" Dim exp As New Regex("CType\((.+), Int32\)") str = exp.Replace(str, "CInt($1)") But this will match the entire string and replace it. I was thinking of doing a recursive function to find the outer most match, and then work inwards, but that still presents a problem with things like CType(replaceChars(I), Int32)), Chr(CType(replacementChars(I), Int32) Any tips would be appreciated. Input returnString.Replace(Chr(CType(replaceChars(I), Int32)), Chr(CType(replacementChars(I), Int32))) Output: returnString.Replace(Chr(CInt(replaceChars(I))),Chr(CInt(replacementChars(I)))) Edit: Been working on it a little more and have a recursive function that I'm still working out the kinks in. Recursion + regex. it kinda hurts. Private Function FindReplaceCInts(ByVal strAs As String) As String System.Console.WriteLine(String.Format("Testing : {0}", strAs)) Dim exp As New Regex("CType\((.+), Int32\)") If exp.Match(strAs).Success Then For Each match As Match In exp.Matches(strAs) If exp.Match(match.Value.Substring(2)).Success Then Dim replaceT As String = match.Value.Substring(2) Dim Witht As String = FindReplaceCInts(match.Value.Substring(2)) System.Console.WriteLine(strAs.IndexOf(replaceT)) strAs.Replace(replaceT, Witht) End If Next strAs = exp.Replace(strAs, "CInt($1)") End If Return strAs End Function Cheers,

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• R + Bioconductor : combining probesets in an ExpressionSet

  - by Mike Dewar

  Hi, First off, this may be the wrong Forum for this question, as it's pretty darn R+Bioconductor specific. Here's what I have: library('GEOquery') GDS = getGEO('GDS785') cd4T = GDS2eSet(GDS) cd4T <- cd4T[!fData(cd4T)$symbol == "",] Now cd4T is an ExpressionSet object which wraps a big matrix with 19794 rows (probesets) and 15 columns (samples). The final line gets rid of all probesets that do not have corresponding gene symbols. Now the trouble is that most genes in this set are assigned to more than one probeset. You can see this by doing gene_symbols = factor(fData(cd4T)$Gene.symbol) length(gene_symbols)-length(levels(gene_symbols)) [1] 6897 So only 6897 of my 19794 probesets have unique probeset - gene mappings. I'd like to somehow combine the expression levels of each probeset associated with each gene. I don't care much about the actual probe id for each probe. I'd like very much to end up with an ExpressionSet containing the merged information as all of my downstream analysis is designed to work with this class. I think I can write some code that will do this by hand, and make a new expression set from scratch. However, I'm assuming this can't be a new problem and that code exists to do it, using a statistically sound method to combine the gene expression levels. I'm guessing there's a proper name for this also but my googles aren't showing up much of use. Can anyone help?

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