I use pyro for basic management of parallel jobs on a compute cluster. I just moved to a cluster where I will be responsible for using all the cores on each compute node. (On previous clusters, each core has been a separate node.) The python multiprocessing module seems like a good fit for this. I notice it can also be used for remote-process communication. If anyone has used both frameworks for remote-process communication, I'd be grateful to hear how they stack up against each other. The obvious benefit of the multiprocessing module is that it's built-in from 2.6. Apart from that, it's hard for me to tell which is better.