Specs: Q6600, evga 780I sli mobo, 4gig RAM, logitech MX518, windows 7 64bit, evga gtx 260, 650W power supply (single rail)

The problem I am having is my mouse will reconnect/disconnect (will even hear the sounds from windows) and the light on the bottom of the mouse will turn off/turn on as it starts working again.

It really sucks to be playing a game (and happens on desktop as well) for the mouse to just die out for a few seconds and come back. Sometimes it will not happen for days and other times it will do it 2 or more times within 15 seconds.

I have tried two different wired mice, have tried multiple USB ports (on front of computer, back of computer, have also used a USB hub and have also plugged in a card that connects to the USB connectors on the motherboard and adds a few usb ports to the back of the computer, and I also bought a USB 2.0 PCI card and that did not help).

Nothing else seems to reconnect like this, my usb keyboard has never once cut out like the mouse does and neither have any of the other devices I have connected (webcam, usb hub, various devices sometimes connected through usb cables, and IR reciever for windows media center remote). I have disconnected all usb devices except for my keyboard and mouse and the problem still occurs.

I guess it could be something wrong with my motherboard but since no other devices behave similarly I'm just hoping that it is some kind of driver conflict. Installing logitech's drivers has had no effect. It seemed at first that if I go to device manager and uninstall HID-compliant mouse (that and logitech mx518 are listed) that would fix it but it doesn't seem to work anymore or at least not every time (it keeps reinstalling).

I have googled "usb mouse disconnects and reconnects" and it seems to be fairly common but none of those were resolved.

To stick some easy steps:

It happens with or without the drivers installed

It has happened with multiple mice on the same computer

Bios is the latest version (P08)

Motherboard drivers are the latest version

Device manager is listing no problems on any USB devices

Happens with every usb port, even addon usb cards

Happens when all usb devices aside from mouse and keyboard are unplugged

I read that maybe it is an IRQ conflict and I tried to look into that but did not really know what was going on, but didn't see anything obviously wrong.

Thanks for any help guys, its driving me crazy!