Since the vast majority of monitors are 16-bit color or more, including mobile devices, does it make sense to even consider web-safe colors when choosing color schemes? Or is it something that ought to be relegated to history as a piece of trivia?

For those of you that don't know what web-safe colors are:

Another set of 216 color values is commonly considered to be the "web-safe" color palette, developed at a time when many computer displays were only capable of displaying 256 colors. A set of colors was needed that could be shown without dithering on 256-color displays; the number 216 was chosen partly because computer operating systems customarily reserved sixteen to twenty colors for their own use; it was also selected because it allows exactly six shades each of red, green, and blue (6 × 6 × 6 = 216).

The list of colors is often presented as if it has special properties that render them immune to dithering. In fact, on 256-color displays applications can set a palette of any selection of colors that they choose, dithering the rest. These colors were chosen specifically because they matched the palettes selected by the then leading browser applications. ^[Wikipedia]