Currently I am trying to run VirtualBox on my second monitor, with a dedicated mouse and keyboard. However, doing so has not proven easy. There has been times where the mouse works, but not the keyboard, vice versa, or nothing works at all. The biggest problem I am running into is this:

When enabling the USB mouse and keyboard from the VM, I get an error: 'USB Device is busy with a previous request.' The only thing that is using second mouse and keyboard, however, is Windows. The other error I have received stated that the VM was unable to create a proxy for the device. Additionally, the VM occasionally will disable the secondary keyboard entirely, requiring me to unplug and replug it into my PC to re-enable it again.

Keyboard auto-capture is disabled, and while a solution I was reading online stated to turn off mouse integration, that option is grayed out on my machine.