A Perl/CGI webapp that has been running fine for almost a year has started to randomly been unable to connect to a remotely hosted MySQL. The Error thrown is : Can't connect to MySQL server on 'xx.x.xxx.xx' (111) Reloading the page often solves the problem The client is using Perl, DBI and SSL to connect to MySQL using the same configuration file each time. MySQL 5.0 Server Running RH EL5 Quad-Core AMD Opteron(tm) Processor 2374 HE, 8 cores Real Memory: 15.73 GB total, 11.81 GB used allows networking in my.cnf max-connections are not being met load is low. The servers firewall is open to the client's subnet. The mysql user has permissions from the client's subnet. I have my host looking into the problem but so far we're all stumped as to way the occasional connection is (increasingly getting refused) Any advice what to check that would cause the random refusal of connections?